We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Periodontal disease in patients with WHIM syndrome.
- Authors
Brenchley, Laurie; McDermott, David H.; Gardner, Pamela J.; Silva, Lakmali M.; Gao, Ji‐Liang; Cho, Elena; Velez, Daniel; Moutsopoulos, Niki M.; Murphy, Philip M.; Fraser, David
- Abstract
Aim: WHIM (warts, hypogammaglobulinaemia, infections and myelokathexis) syndrome is a rare combined primary immunodeficiency disease caused by gain‐of‐function (GOF) mutations in the chemokine receptor CXCR4 and includes severe neutropenia as a common feature. Neutropenia is a known risk factor for periodontitis; however, a detailed periodontal evaluation of a WHIM syndrome cohort is lacking. This study aimed to establish the evidence base for the periodontal status of patients with WHIM syndrome. Materials and Methods: Twenty‐two adult WHIM syndrome patients and 22 age‐ and gender‐matched healthy volunteers (HVs) were evaluated through a comprehensive medical and periodontal examination. A mouse model of WHIM syndrome was assessed for susceptibility to naturally progressing or inducible periodontitis. Results: Fourteen patients with WHIM syndrome (63.6%) and one HV (4.5%) were diagnosed with Stage III/IV periodontitis. No WHIM patient presented with the early onset, dramatic clinical phenotypes typically associated with genetic forms of neutropenia. Age, but not the specific CXCR4 mutation or absolute neutrophil count, was associated with periodontitis severity in the WHIM cohort. Mice with a Cxcr4 GOF mutation did not exhibit increased alveolar bone loss in spontaneous or ligature‐induced periodontitis. Conclusions: Overall, WHIM syndrome patients presented with an increased severity of periodontitis despite past and ongoing neutrophil mobilization treatments. GOF mutations in CXCR4 may be a risk factor for periodontitis in humans.
- Subjects
PRIMARY immunodeficiency diseases; RISK assessment; BONE resorption; PERIODONTIUM examination; RESEARCH funding; SEVERITY of illness index; AGGRESSIVE periodontitis; GAIN-of-function mutations; NEUTROPENIA; PERIODONTITIS; ORAL health; CELL receptors; PHENOTYPES; DISEASE risk factors; DISEASE complications
- Publication
Journal of Clinical Periodontology, 2024, Vol 51, Issue 4, p464
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.13940