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- Title
Increased expression of resistin in ectopic endometrial tissue of women with endometriosis.
- Authors
Oh, Yoon Kyung; Ha, Young Ran; Yi, Kyong Wook; Park, Hyun Tae; Shin, Jung‐Ho; Kim, Tak; Hur, Jun‐Young
- Abstract
Problem Inflammation is a key process in the establishment and progression of endometriosis. Resistin, an adipocytokine, has biological properties linked to immunologic functions, but its role in endometriosis is unclear. Method of study Resistin gene expression was examined in eutopic and ectopic endometrial tissues from women with (n=25) or without (n=25) endometriosis. Resistin mRNA and protein levels were determined in endometrial tissue using quantitative real-time reverse transcription PCR and Western blotting, following adipokine profiling arrays. Results Resistin protein was detected in human endometrial tissues using an adipokine array test. Resistin mRNA and protein levels were significantly higher in ectopic endometrial tissue of patients with endometriosis than in normal eutopic endometrial tissue. Conclusion Our results indicate that resistin is differentially expressed in endometrial tissues from women with endometriosis and imply a role for resistin in endometriosis-associated pelvic inflammation.
- Subjects
PELVIC diseases; TREATMENT of endometriosis; CYTOKINES; ADIPOKINES; MUCOUS membranes
- Publication
American Journal of Reproductive Immunology, 2017, Vol 78, Issue 5, pn/a
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/aji.12726