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- Title
The Role of Sertoli Cell Hormones in Male Preponderance Observed in Autism Spectrum Disorder.
- Authors
ÇELİK GÖKSOY, Şeyda; TANIR, Yaşar; SOYLU, Nusret; BAKİ, Adile Merve; VURAL, Pervin; KARAYAĞMURLU, Ali
- Abstract
Introduction: There is a significant, but poorly understood, male preponderance in prevalence of autism spectrum disorder (ASD). The aim of this study was to examine the relationship between male preponderance in ASD and Inhibin B (InhB) and Anti-Müllerian hormone (AMH) levels and the 2D/4D finger ratio associated with fetal androgen exposure. Methods: 42 patients with ASD and 42 neurotypical controls between the ages of 5 and 10 were included. ASD diagnosis and severity were determined using K-SADS PL (Kiddie-SADS -- Present and Life Time) Version 2016 and the Childhood Autism Rating Scale (CARS). Serum InhB and AMH were measured. The 2D/4D finger length ratio was also calculated for hand anthropometric measurements. Results: Serum InhB levels were higher in children diagnosed with ASD compared to the neurotypical controls (p=0.003). Serum AMH levels were similar in both groups. Positive correlation was determined between AMH and CARS scores (r=0.315, p=0.05). 2D/4D finger ratios in the ASD group were significantly lower than in the control group (p<0.001). Conclusion: The study findings suggest that InhB, AMH, and fetal testosterone may be associated with male preponderance in ASD. More research is now required for a better understanding of this subject.
- Subjects
DIAGNOSIS of autism; SEX hormones; ANDROGENS; TESTOSTERONE; PRENATAL exposure delayed effects; RESEARCH funding; SEX distribution; GLYCOPROTEINS; TESTIS; FOLLICLE-stimulating hormone; ANTHROPOMETRY; COMPARATIVE studies
- Publication
Archives of Neuropsychiatry / Nöropsikiyatri Arşivi, 2024, Vol 61, Issue 2, p141
- ISSN
1300-0667
- Publication type
Article
- DOI
10.29399/npa.28378