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- Title
Anti-Inflammatory Effect of Apigenin on LPS-Induced Pro-Inflammatory Mediators and AP-1 Factors in Human Lung Epithelial Cells.
- Authors
Patil, Rajeshwari; Babu, R.; Naveen Kumar, M.; Kiran Kumar, K.; Hegde, Shubha; Nagesh, Rashmi; Ramesh, Govindarajan; Sharma, S.
- Abstract
Apigenin is one of the plant flavonoids present in fruits and vegetables, acting as an important nutraceutical component. It is recognized as a potential antioxidant, antimicrobial, and anti-inflammatory molecule. In the present study, the mechanism of anti-inflammatory action of apigenin on lipopolysaccharide (LPS)-induced pro-inflammatory cytokines and activator protein-1 (AP-1) factors in human lung A549 cells was investigated. The anti-inflammatory activity of apigenin on LPS-induced inflammation was determined by analyzing the expression of pro-inflammatory cytokines, nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and different AP-1 factors. Apigenin significantly inhibited the LPS-induced expression of iNOS, COX-2, expression of pro-inflammatory cytokines (IL-1β, IL-2, IL-6, IL-8, and TNF-α), and AP-1 proteins (c-Jun, c-Fos, and JunB) including nitric oxide production. Study confirms the anti-inflammatory effect of apigenin by inhibiting the expression of inflammatory mediators and AP-1 factors involved in the inflammation and its importance in the treatment of lung inflammatory diseases.
- Subjects
ANTI-inflammatory agents; APIGENIN; LIPOPOLYSACCHARIDES; INFLAMMATION; EPITHELIAL cells; LUNG diseases
- Publication
Inflammation, 2016, Vol 39, Issue 1, p138
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-015-0232-z