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- Title
Higher Percentage of CD3CD154 T Lymphocytes Predicts Efficacy of TNF-α Inhibitors in Active Axial SpA Patients.
- Authors
Lin, Zhiming; Lin, Qu; Liao, Zetao; Li, Qiuxia; Zhang, Fucheng; Wei, Qiujing; Cao, Shuangyan; Gu, Jieruo
- Abstract
The objective of this study was to evaluate which subtypes of T lymphocytes (CD3CD28 and CD3CD154) could predict clinical efficacy after TNF-α inhibitor treatment in active axial SpA patients. Patients who fulfilled Assessment of SpondyloArthritis international Society (ASAS) criteria for axial SpA had a BASDAI of ≥40 mm. All patients received TNF-α inhibitor treatment for 12 weeks. ASAS20 was used to evaluate the effect of the treatment at week 12. We detected the percentage of CD3CD28 and CD3CD154 T lymphocytes on lymphocyte cells in the peripheral blood in patients and healthy controls. We evaluated whether the percentage of the above subtypes of T lymphocytes could predict clinical efficacy by ROC curve analysis. Fifty-eight healthy controls and 74 active axial SpA patients were included. Mean age was 26.28 ± 9.08 and 26.95 ± 8.13 years for healthy controls and patients, respectively ( p = 0.767). The percentage of CD3CD154 T lymphocytes was significantly higher in axial SpA patients than in healthy controls (1.62 ± 1.89 % vs 0.79 ± 0.52 %, p < 0.0005). At baseline, the percentage of CD3CD154 T lymphocytes was significantly higher in HLA-B27() patients than HLA-B27() ones (HLA-B27 vs HLA-B27:1.77 ± 1.95 % vs 0.41 ± 0.27 %, p = 0.005). Compared with baseline, the percentage of CD3CD154 T lymphocytes significantly decreased to 0.87 ± 0.49 % at week 12 ( p < 0.0005). Moreover, we found higher percentage of CD3CD154 T lymphocytes could predict clinical efficacy of SpA patients with TNF-α inhibitor treatment (AUC = 0.733, p = 0.014). High percentage of CD3CD154 is over-expressed on lymphocytes in peripheral blood of active SpA patients and can be down-regulated by TNF-α inhibitor therapy. High-percentage of CD3CD154 T lymphocytes may predict clinical efficacy of TNF-α inhibitor treatment in active axial SpA patients.
- Subjects
T cells; TUMOR necrosis factor regulation; SPONDYLOARTHROPATHIES; TREATMENT effectiveness; RECEIVER operating characteristic curves; THERAPEUTICS
- Publication
Inflammation, 2014, Vol 37, Issue 6, p2056
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-014-9938-6