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- Title
Neisseria gonorrhoeae isolates from four centres in Papua New Guinea remain susceptible to amoxycillin-clavulanate therapy.
- Authors
Toliman, Pamela J.; Lupiwa, Tony; Law, Gregory J.; Reeder, John C.; Siba, Peter M.
- Abstract
Antibiotic-resistant strains of Neisseria gonorrrhoeae have the potential to undermine treatment and control of gonorrhoea, which remains a highly prevalent sexually transmitted infection (STI) in Papua New Guinea (PNG). The standard treatment regimen for gonorrhoea in PNG based on amoxycillin and clavulanic acid (amoxycillin-clavulanate) was introduced about 15 years ago and there is some concern that over time circulating strains may have developed resistance to this therapy. To investigate this, N. gonorrhoeae isolates (n=52) were collected from STI clinics in geographically representative centres in PNG and tested for their in vitro susceptibility to a range of antibiotics. All 52 isolates tested were found susceptible to amoxycillin-clavulanate, despite 40% (n=21) being penicillinase producers and thus resistant to penicillin. These findings indicate that amoxycillin-clavulanate therapy remains an effective treatment for gonococcal infections in PNG, and support the maintenance of the present standard treatment for gonorrhoea in PNG.
- Subjects
PAPUA New Guinea; NEISSERIA gonorrhoeae; GONORRHEA treatment; NEISSERIA infections; SEXUALLY transmitted diseases; ANTIBACTERIAL agents; ANTI-infective agents; THERAPEUTICS
- Publication
Papua New Guinea Medical Journal, 2010, Vol 53, Issue 1/2, p15
- ISSN
0031-1480
- Publication type
Article