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- Title
A 7-year surveillance for ESBL-producing Escherichia coli and Klebsiella pneumoniae at a university hospital in Taiwan: the increase of CTX-M-15 in the ICU.
- Authors
Shu, J. C.; Chia, J. H.; Kuo, A. J.; Su, L. H.; Wu, T. L.
- Abstract
To monitor the changing trend of extended-spectrum β-lactamase (ESBL)-producing bacteria, a 7-year continuous study was launched in 2001 at the largest tertiary hospital in Taiwan. A significant increase over the study period was evident for ESBL-producing isolates of Escherichia coli (4·8-10·0%) and Klebsiella pneumoniae (15·0-23·4%). Molecular investigation conducted in three separate periods revealed the prevalent ESBL types and their genetic relatedness. CTX-M-producing isolates (73·8%) were more prevalent than SHV-type ESBLs (37·0%), the most frequent being CTX-M-14 (34·3%), CTX-M-3 (25·9%), and SHV-12 (25·7%). However, a marked increase of CTX-M-15-producing isolates from 2.1% in 2002 to 29.6% in 2007 was also noted. The increase of ESBL-producing isolates in both species may be mainly due to the horizontal transmission of resistance plasmids, while clonal expansion of some epidemic strains further added to the dispersion of ESBL-producing K. pneumoniae.
- Subjects
TAIWAN; BETA lactamases; BACTERIAL diseases; KLEBSIELLA pneumoniae; ESCHERICHIA coli; UNIVERSITY hospitals
- Publication
Epidemiology & Infection, 2010, Vol 138, Issue 2, p253
- ISSN
0950-2688
- Publication type
Article
- DOI
10.1017/S0950268809990409