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- Title
Combined Effects of Early Life Stress and Prolonged Exposure to Western Diet on Emotional Responses and Gut Microbiota.
- Authors
López-Taboada, Isabel; Arboleya, Silvia; Sal-Sarria, Saúl; Gueimonde, Miguel; González-Pardo, Héctor; Conejo, Nélida M.
- Abstract
Background: Exposure to early life stress (ELS) and maternal consumption of a high-fat and high-sugar diet can have detrimental effects on adult emotional responses. The microbiota and gut-brain axis have been proposed as playing a mediating role in the regulation of stress and emotion. Method: Young male rats were exposed to maternal separation (MS) together with maternal and postnatal consumption of a HFS diet (45%kcal saturated fat, 17%kcal sucrose). Anxiety-like behaviour was evaluated using an elevated zero-maze, and depression-like behaviour using the forced-swim and sucrose preference tests. Microbiota composition and derived metabolites were also analysed in faecal samples using a gas chromatograph and mass spectrometry. Results: Combined exposure to MS and lifelong consumption of a HFS diet partially reversed the abnormal anxiety-like and depression-like behaviours in early adulthood caused by each adverse factor alone. Diet composition had a greater negative impact than ELS exposure on the gut microbiota, and both environmental factors interacted with microbiota composition partially counteracting their negative effects. Conclusions: The effects of exposure to early life stress and a HFS diet independently are partially reversed after the combination of both factors. These results suggest that ELS and diet interact to modulate adult stress response and gut microbiota.
- Subjects
STRESS in children; WESTERN diet; EMOTIONS; HIGH-fat diet; GUT microbiome; METABOLITES; MASS spectrometry; SUCROSE; ANXIETY; MENTAL depression
- Publication
Psicothema, 2024, Vol 36, Issue 2, p133
- ISSN
0214-9915
- Publication type
Article
- DOI
10.7334/psicothema2023.287