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- Title
Determinant of Insulin Resistance in Patients with Schizophrenia.
- Authors
Chul Sik Kim; Jong Suk Park; Min Ho Cho; Hai Jin Kim; Ji Sun Nam; Han Young Jung; Ji Eun Yoon; Chul Woo Akin; Young Duk Song; Bong Soo Cha; Eun Jig Lee; Sung Kil Lim; Kyung Rae Kim; Hyun Chul Lee
- Abstract
Patients with schizophrenia are reported to have twice higher risk of developing type 2 diabetes mellitus and impaired glucose tolerance in many epidemiologic studies. The aim the study is to demonstrate the determinants of insulin resistance and cardiovascular risks in drug naive schizophrenic patients. Sixteen drug naive schizophrenic subjects and 16 sex and age matched control subjects were enrolled. The patients were interviewed for medical history and blood pressure, height, weight, waist circumference (WC), body fat percentage were checked. Lipid profiles, fasting plasma glucose, s-insulin, c-peptide, HbA1c and 24 hours urine cortisol level were collected. HOMA-IR was used to assess insulin resistance. In this study, newly diagnosed schizophrenic patients were 13 and drug naïve patients were 6. There were no differences in age, sex, weight, height, BMI, WC, body fat percentage between schizophrenia and the control group. In laboratory tests, triglyceride level was increased in schizophrenic patients than the control group. But there were no differences in blood pressure, fasting blood glucose, HbA1c, insulin, total cholesterol, HDL-C, LDL-C between the two groups. HOMA IR was increased in schizophrenic patient group but there was no statistical significance. In correlation and regression analyses, only 24 hour urine cortisol level had significant positive correlation with HOMA-IR in schizophrenic patients (r = 0.797, p = 0.002; β = 0.646, p= 0.02). In the control group, with simple regression, age, WC had positive correlation with HOMA-IR, but in multiple regression analysis, there was no variable that had significant correlation with HOMA-IR. There was no significant difference in fasting blood glucose, blood pressure, cholesterol and HOMA-IR between drug naive schizophrenic patients. Moreover age, WC had close positive correlation with HOMA-IR in the control group, but only 24 hour urine cortisol level had close correlation with HOMA-IR in the control group. This suggest that in schizophrenic patients, instead of waist circumference and body fat distribution, which are important predictors of insulin resistance in normal population, hyperactivation of hypothalamus -- pituitary -- adrenal (H-P-A) axis may act as an important determinant of insulin resistance.
- Subjects
INSULIN resistance; PEOPLE with schizophrenia; TYPE 2 diabetes; CARDIOVASCULAR diseases risk factors; HYPOTHALAMIC-pituitary-adrenal axis
- Publication
Diabetes, 2007, Vol 56, pA662
- ISSN
0012-1797
- Publication type
Article