We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Telocytes/CD34+ Stromal Cells in the Normal, Hyperplastic, and Adenomatous Human Parathyroid Glands.
- Authors
Díaz-Flores, Lucio; Gutiérrez, Ricardo; González-Gómez, Miriam; García, Maria del Pino; Carrasco, Jose Luis; Madrid, Juan Francisco; Díaz-Flores Jr., Lucio
- Abstract
Telocytes/CD34+ stromal cells (TCs/CD34+ SCs) have been studied in numerous organs and tissues, but their presence and characteristics in the parathyroid glands have not been explored. Using immunological and ultrastructural procedures, we assess the location, arrangement, and behavior of TCs/CD34+ SCs in normal human parathyroids, during their development and in their most frequent pathologic conditions. In normal parathyroids, TCs/CD34+ SCs show a small somatic body and long thin processes with a moniliform aspect, form labyrinthine systems, connect other neighboring TCs/CD34+ SCs, vessels, adipocytes, and parenchymal cells directly or by extracellular vesicles, and associate with collagen I. TCs/CD34+ SCs and collagen I are absent around vessels and adipocytes within parenchymal clusters. In developing parathyroids, TCs/CD34+ SC surround small parenchymal nests and adipocytes. In hyperplastic parathyroids, TCs/CD34+ SCs are prominent in some thickened internodular septa and surround small extraglandular parenchymal cell nests. TCs/CD34+ SCs are present in delimiting regions with compressed parathyroids and their capsule in adenomas but absent in most adenomatous tissue. In conclusion, TCs/CD34+ SCs are an important cellular component in the human parathyroid stroma, except around vessels within parenchymal nests. They show typical characteristics, including those of connecting cells, are present in developing parathyroids, and participate in the most frequent parathyroid pathology, including hyperplastic and adenomatous parathyroids.
- Subjects
STROMAL cells; PARATHYROID glands; CELL anatomy; FAT cells; EXTRACELLULAR vesicles; COLLAGEN; ADIPOGENESIS
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 15, p12118
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms241512118