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- Title
P2X 7 Receptor and Extracellular Vesicle Release.
- Authors
Golia, Maria Teresa; Gabrielli, Martina; Verderio, Claudia
- Abstract
Extensive evidence indicates that the activation of the P2X7 receptor (P2X7R), an ATP-gated ion channel highly expressed in immune and brain cells, is strictly associated with the release of extracellular vesicles. Through this process, P2X7R-expressing cells regulate non-classical protein secretion and transfer bioactive components to other cells, including misfolded proteins, participating in inflammatory and neurodegenerative diseases. In this review, we summarize and discuss the studies addressing the impact of P2X7R activation on extracellular vesicle release and their activities.
- Subjects
EXTRACELLULAR vesicles; CELL anatomy; ION channels; NEURODEGENERATION; BIOACTIVE compounds; PURINERGIC receptors
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 12, p9805
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24129805