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- Title
Revisiting Platinum-Based Anticancer Drugs to Overcome Gliomas.
- Authors
Jeon, Jaewan; Lee, Sungmin; Kim, Hyunwoo; Kang, Hyunkoo; Youn, HyeSook; Jo, Sunmi; Youn, BuHyun; Kim, Hae Yu; Gorji, Ali
- Abstract
Although there are many patients with brain tumors worldwide, there are numerous difficulties in overcoming brain tumors. Among brain tumors, glioblastoma, with a 5-year survival rate of 5.1%, is the most malignant. In addition to surgical operations, chemotherapy and radiotherapy are generally performed, but the patients have very limited options. Temozolomide is the most commonly prescribed drug for patients with glioblastoma. However, it is difficult to completely remove the tumor with this drug alone. Therefore, it is necessary to discuss the potential of anticancer drugs, other than temozolomide, against glioblastomas. Since the discovery of cisplatin, platinum-based drugs have become one of the leading chemotherapeutic drugs. Although many studies have reported the efficacy of platinum-based anticancer drugs against various carcinomas, studies on their effectiveness against brain tumors are insufficient. In this review, we elucidated the anticancer effects and advantages of platinum-based drugs used in brain tumors. In addition, the cases and limitations of the clinical application of platinum-based drugs are summarized. As a solution to overcome these obstacles, we emphasized the potential of a novel approach to increase the effectiveness of platinum-based drugs.
- Subjects
ANTINEOPLASTIC agents; GLIOMAS; BRAIN tumors; SURVIVAL rate; DRUG utilization; CISPLATIN; CARBOPLATIN
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 10, p5111
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22105111