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- Title
Resveratrol in Cancer Patients: From Bench to Bedside.
- Authors
Berretta, Massimiliano; Bignucolo, Alessia; Di Francia, Raffaele; Comello, Francesco; Facchini, Gaetano; Ceccarelli, Manuela; Iaffaioli, Rosario Vincenzo; Quagliariello, Vincenzo; Maurea, Nicola
- Abstract
Resveratrol (3,5,4′-trihydroxystilbene) is a natural phytoalexin that accumulates in several vegetables and fruits like nuts, grapes, apples, red fruits, black olives, capers, red rice as well as red wines. Being both an extremely reactive molecule and capable to interact with cytoplasmic and nuclear proteins in human cells, resveratrol has been studied over the years as complementary and alternative medicine (CAM) for the therapy of cancer, metabolic and cardiovascular diseases like myocardial ischemia, myocarditis, cardiac hypertrophy and heart failure. This review will describe the main biological targets, cardiovascular outcomes, physico-chemical and pharmacokinetic properties of resveratrol in preclinical and clinical models implementing its potential use in cancer patients.
- Subjects
RESVERATROL; CARDIAC hypertrophy; CANCER patients; NUCLEAR proteins; CORONARY disease
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 8, p2945
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21082945