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- Title
Interaction of DNA with Simple and Mixed Ligand Copper(II) Complexes of 1,10-Phenanthrolines as Studied by DNA-Fiber EPR Spectroscopy.
- Authors
Chikira, Makoto; Chew Hee Ng; Palaniandavar, Mallayan
- Abstract
The interaction of simple and ternary Cu(II) complexes of 1,10-phenanthrolines with DNA has been studied extensively because of their various interesting and important functions such as DNA cleavage activity, cytotoxicity towards cancer cells, and DNA based asymmetric catalysis. Such functions are closely related to the DNA binding modes of the complexes such as intercalation, groove binding, and electrostatic surface binding. A variety of spectroscopic methods have been used to study the DNA binding mode of the Cu(II) complexes. Of all these methods, DNA-fiber electron paramagnetic resonance (EPR) spectroscopy affords unique information on the DNA binding structures of the complexes. In this review we summarize the results of our DNA-fiber EPR studies on the DNA binding structure of the complexes and discuss them together with the data accumulated by using other measurements.
- Subjects
DNA; LIGANDS (Biochemistry); COPPER compounds; COMPLEX compounds; ELECTRON paramagnetic resonance spectroscopy; SCISSION (Chemistry); DNA-binding proteins
- Publication
International Journal of Molecular Sciences, 2015, Vol 16, Issue 9, p22754
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms160922754