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- Title
Phosphatidylethanol in Blood as a Marker of Chronic Alcohol Use: A Systematic Review and Meta-Analysis.
- Authors
Viel, Guido; Rafael, Boscolo-Berto; Cecchetto, Giovanni; Fais, Paolo; Nalesso, Alessandro; Ferrara, Santo Davide
- Abstract
The present paper aims at a systematic review of the current knowledge on phosphatidylethanol (PEth) in blood as a direct marker of chronic alcohol use and abuse. In March 2012, the search through gMeSHh and gfree-texth protocols in the databases Medline/PubMed, SCOPUS, Web of Science, and Ovid/Embase, combining the terms phosphatidylethanol and alcohol, provided 444 records, 58 of which fulfilled the inclusion criteria and were used to summarize the current evidence on the formation, distribution and degradation of PEth in human blood: (1), the presence and distribution of different PEth molecular species (2), the most diffused analytical methods devoted to PEth identification and quantization (3), the clinical efficiency of total PEth quantification as a marker of chronic excessive drinking (4), and the potential utility of this marker for identifying binge drinking behaviors (5). Twelve papers were included in the meta-analysis and the mean (M) and 95% confidence interval (CI) of total PEth concentrations in social drinkers (DAI 60 g/die; M = 0.288 µM; CI 0.208-0.367 µM) and heavy drinkers (DAI ≤ 60 g/die; M = 3.897 µM; CI 2.404-5.391 µM) were calculated. The present analysis demonstrates a good clinical efficiency of PEth for detecting chronic heavy drinking.
- Subjects
ALCOHOLISM; BLOOD testing; BIOMARKERS; PHOSPHOLIPIDS; ETHANOL; MASS spectrometry; SYSTEMATIC reviews
- Publication
International Journal of Molecular Sciences, 2012, Vol 13, Issue 11, p14788
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms131114788