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- Title
Rosemary Extracts Upregulate Nrf2, Sestrin2, and MRP2 Protein Level in Human Hepatoma HepG2 Cells.
- Authors
Tong, Xiao-pei; Ma, Yan-xia; Quan, Dan-ni; Zhang, Ling; Yan, Miao; Fan, Xin-rong
- Abstract
In the past few decades, the incidence of liver cancer has been rapidly rising across the world. Rosemary is known to possess antioxidant activity and is used as natural antioxidant food preservative. It is proposed to have anticancer activity in treating different tumor models. In this study, we try to explore the impact of rosemary extracts on upregulating the level of Nrf2 and Nrf2-regulatory proteins, Sestrin2 and MRP2 in HepG2 cells, and to speculate its potential mechanism. The anticancer activity of rosemary extract, including its polyphenolic diterpenes carnosic acid and carnosol, was evaluated to understand the potential effect on HepG2 cells. Rosemary extract, carnosic acid, and carnosol induced the expression of Sestrin2 and MRP2 associate with enhancement of Nrf2 protein level in HepG2 cells, in which carnosic acid showed most obvious effect. Although the activation pathway of Nrf2/ARE was not exactly assessed, it can be assumed that the enhancement of expression of Sestrin2 and MRP2 may result from upregulation of Nrf2.
- Subjects
THERAPEUTIC use of antioxidants; HEPATOCELLULAR carcinoma; THERAPEUTIC use of plant extracts; PREVENTION; ROSEMARY; THERAPEUTICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2017, Vol 2017, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2017/7359806