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- Title
Limited HIV Infection of Central Memory and Stem Cell Memory CD4+ T Cells Is Associated with Lack of Progression in Viremic Individuals.
- Authors
Klatt, Nichole R.; Bosinger, Steven E.; Peck, Melicent; Richert-Spuhler, Laura E.; Heigele, Anke; Gile, Jillian P.; Patel, Nirav; Taaffe, Jessica; Julg, Boris; Camerini, David; Torti, Carlo; Martin, Jeffrey N.; Deeks, Steven G.; Sinclair, Elizabeth; Hecht, Frederick M.; Lederman, Michael M.; Paiardini, Mirko; Kirchhoff, Frank; Brenchley, Jason M.; Hunt, Peter W.
- Abstract
A rare subset of HIV-infected individuals, designated viremic non-progressors (VNP), remain asymptomatic and maintain normal levels of CD4+ T-cells despite persistently high viremia. To identify mechanisms potentially responsible for the VNP phenotype, we compared VNPs (average >9 years of HIV infection) to HIV-infected individuals who have similar CD4+ T-cell counts and viral load, but who are likely to progress if left untreated (“putative progressors”, PP), thus avoiding the confounding effect of differences related to substantial CD4+ T cell depletion. We found that VNPs, compared to PPs, had preserved levels of CD4+ stem cell memory cells (TSCM (p<0.0001), which was associated with decreased HIV infection of these cells in VNPs (r = −0.649, p = 0.019). In addition, VNPs had decreased HIV infection in CD4+ central memory (TCM) cells (p = 0.035), and the total number of TCM cells was associated with increased proliferation of memory CD4+ T cells (r = 0.733, p = 0.01). Our results suggest that, in HIV-infected VNPs, decreased infection of CD4+ TCM and TSCM, cells are involved in preservation of CD4+ T cell homeostasis and lack of disease progression despite high viremia.
- Subjects
T cells; VIREMIA; HIV infections; STEM cell research; CD4 antigen
- Publication
PLoS Pathogens, 2014, Vol 10, Issue 8, p1
- ISSN
1553-7366
- Publication type
Article
- DOI
10.1371/journal.ppat.1004345