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- Title
PPARγ gene polymorphism, C-reactive protein level, BMI and periodontitis in post-menopausal Japanese women.
- Authors
Wang, Yangming; Sugita, Noriko; Yoshihara, Akihiro; Iwasaki, Masanori; Miyazaki, Hideo; Nakamura, Kazutoshi; Yoshie, Hiromasa
- Abstract
<bold>Background: </bold>Several studies have reported inconsistent results regarding the association between the PPARγPro12Ala polymorphism and obesity. Obese individuals had higher C-reactive protein (CRP) levels compared with those of normal weight, and PPARγ activation could significantly reduce serum high-sensitive CRP level. We have previously suggested that the Pro12Ala polymorphism represents a susceptibility factor for periodontitis, which is a known risk factor for increased CRP level.<bold>Objectives: </bold>The aim was to investigate associations between PPARγ gene polymorphism, serum CRP level, BMI and/or periodontitis among post-menopausal Japanese women.<bold>Materials and Methods: </bold>The final sample in this study comprised 359 post-menopausal Japanese women. Periodontal parameters, including PD, CAL and BOP, were measured per tooth. PPARγPro12Ala genotype was determined by PCR-RFLP. Hs-CRP value was measured by a latex nephelometry assay.<bold>Results: </bold>No significant differences in age, BMI or periodontal parameters were found between the genotypes. The percentages of sites with PD ≥ 4 mm were significantly higher among the hsCRP ≥ 1 mg/l group than the hsCRP < 1 mg/l group (p = 0.003). Positive correlations were found between serum hsCRP levels and the percentages of sites with PD ≥ 4 mm (p = 0.043) in PPARγ Ala allele carriers, and BMI (p = 0.033) in non-carriers. After adjustment for model covariates, BMI was significantly associated with serum hsCRP level.<bold>Conclusion: </bold>The PPARγPro12Ala polymorphism was not independently associated with periodontitis, serum CRP level or BMI in post-menopausal Japanese women. However, serum hsCRP level correlated with periodontitis in Ala allele carriers, and with BMI in non-carriers.
- Subjects
JAPAN; GENETIC polymorphism research; POPULATION genetics; AMPLIFIED fragment length polymorphism; C-reactive protein; ACUTE phase proteins; DISEASE susceptibility; GENETIC polymorphisms; PERIODONTAL disease; PERIODONTICS; PERIODONTITIS; PROTEINS; REGRESSION analysis; BODY mass index; POSTMENOPAUSE; GENOTYPES
- Publication
Gerodontology, 2016, Vol 33, Issue 1, p44
- ISSN
0734-0664
- Publication type
journal article
- DOI
10.1111/ger.12110