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- Title
Actinomicetos: mecanismos de patogenicidad.
- Authors
Estela Castrillón-Rivera, Laura; Palma-Ramos, Alejandro; Ismael Castañeda-Sánchez, Jorge
- Abstract
Actinomycetes are a diverse bacterial group responsible for several diseases, such as tuberculosis, mycetoma, nocardiosis, allergic pneumonia, actinomycosis, erythrasma, plantar axillary trichomycosis and dermatitis, among others. The knowledge of the chemical composition of the various microbial structures and the biological activity they trigger is decisive to know its origin and pathogenic aspects. Therefore, the magnitude of the damage caused by these bacteria is the consequence of their recognition and response to these pathogenicity factors, as well as by the host's resistance mechanisms. In addition to the great induction capacity of biological processes associated with their structural components, actinomycetes have developed various strategies that are associated with their virulence, such as: survival in phagocytic cells, deviation of apoptotic mechanisms towards necrosis cell, biofilm formation, release of extracellular vesicles, induction of extracellular traps, release of enzymes and release of toxins. This paper presents some evidence that allows us to understand the host-parasite relationship and that in the future can be considered possible therapeutic targets for the design of new strategies in the treatment of these infections.
- Publication
Dermatología Revista Mexicana, 2020, Vol 64, Issue 5, p556
- ISSN
0185-4038
- Publication type
Article