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- Title
Autoimmune hepatitis as an adverse effect of long-term methotrexate therapy.
- Authors
Ksouda, Kamilia; Affes, Hanen; Atheymen, Rim; Ezzeddine, Mariem; Zeghal, Khaled; Hammami, Serria
- Abstract
Methotrexate (MTX) is one of the most commonly used medicines in the treatment of psoriatic arthritis. The drug can produce steatosis and cirrhosis. Autoimmune hepatitis is a rare and serious adverse effect. We describe the case of a 53-year-old woman who developed autoimmune hepatitis after a long-term use of MTX for psoriatic arthritis. Hepatitis was completely resolved 4 months after stopping this drug. The pathophysiologic mechanisms of a drug-induced autoimmunity are unclear and complex. This report confirms the need to monitor liver enzymes carefully in patients using long-term treatment with MTX for psoriasis or rheumatoid arthritis.
- Subjects
AUTOIMMUNE diseases; HEPATITIS; METHOTREXATE; DRUG side effects; FATTY degeneration; CIRRHOSIS of the liver; AUTOIMMUNITY
- Publication
Indian Journal of Pharmacology, 2014, Vol 46, Issue 6, p649
- ISSN
0253-7613
- Publication type
Case Study
- DOI
10.4103/0253-7613.144940