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- Title
Screening of Bauhinia purpurea Linn. for analgesic and anti-inflammatory activities.
- Authors
Shreedhara, C. S.; Vaidya, V. P.; Vagdevi, H. M.; Latha, K. P.; Muralikrishna, K. S.; Krupanidhi, A. M.
- Abstract
Objectives: Ethanol extract of the stem of Bauhinia purpurea Linn. was subjected to analgesic and anti-inflammatory activities in animal models. Materials and Methods: Albino Wistar rats and mice were the experimental animals respectively. Different CNS depressant paradigms like analgesic activity (determined by Eddy's hot plate method and acetic acid writhing method) and anti-inflammatory activity determined by carrageenan induced paw edema using plethysmometer in albino rats) were carried out, following the intra-peritoneal administration of ethanol extract of Bauhinia purpurea Linn. (BP) at the dose level of 50 mg/kg and 100 mg/kg. Results: The analgesic and anti-inflammatory activities of ethanol extracts of BP were significant (P < 0.001). The maximum analgesic effect was observed at 120 min at the dose of 100 mg/kg (i.p.) and was comparable to that of standard analgin (150 mg/kg) and the percentage of edema inhibition effect was 46.4% and 77% for 50 mg/kg and 100 mg/ kg (i.p) respectively. Anti-inflammatory activity was compared with standard Diclofenac sodium (5 mg/kg). Conclusion: Ethanol extract of Bauhinia purpurea has shown significant analgesic and antiinflammatory activities at the dose of 100 mg/kg and was comparable with corresponding standard drugs. The activity was attributed to the presence of phytoconstituents in the tested extract.
- Subjects
MEDICAL research; ALCOHOL; ANALGESICS; ANTI-inflammatory agents; RAT anatomy
- Publication
Indian Journal of Pharmacology, 2009, Vol 41, Issue 2, p75
- ISSN
0253-7613
- Publication type
Article
- DOI
10.4103/0253-7613.51345