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- Title
Novel insights into metabolic‐associated steatotic liver disease preclinical models.
- Authors
Montero‐Vallejo, Rocío; Maya‐Miles, Douglas; Ampuero, Javier; Martín, Franz; Romero‐Gómez, Manuel; Gallego‐Durán, Rocío
- Abstract
Metabolic‐associated steatotic liver disease (MASLD) encompasses a wide spectrum of metabolic conditions associated with an excess of fat accumulation in the liver, ranging from simple hepatic steatosis to cirrhosis and hepatocellular carcinoma. Finding appropriate tools to study its development and progression is essential to address essential unmet therapeutic and staging needs. This review discusses advantages and shortcomings of different dietary, chemical and genetic factors that can be used to mimic this disease and its progression in mice from a hepatic and metabolic point of view. Also, this review will highlight some additional factors and considerations that could have a strong impact on the outcomes of our model to end up providing recommendations and a checklist to facilitate the selection of the appropriate MASLD preclinical model based on clinical aims.
- Subjects
LIVER diseases; ANIMAL models in research; FATTY liver; HEPATIC fibrosis; CIRRHOSIS of the liver
- Publication
Liver International, 2024, Vol 44, Issue 3, p644
- ISSN
1478-3223
- Publication type
Article
- DOI
10.1111/liv.15830