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- Title
Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study.
- Authors
Petta, Salvatore; Eslam, Mohammed; Valenti, Luca; Bugianesi, Elisabetta; Barbara, Marco; Cammà, Calogero; Porzio, Marianna; Rosso, Chiara; Fargion, Silvia; George, Jacob; Craxì, Antonio
- Abstract
Background & Aims Metabolic syndrome ( MS) and its individual components are associated with the severity and progression of nonalcoholic fatty liver disease ( NAFLD). We sought to evaluate the relationship between MS components and the risk of severe hepatic fibrosis in NAFLD patients discriminated by age. Methods We considered 863 consecutive patients with biopsy-proven NAFLD, who had been fully evaluated for components of MS. Results Multivariate logistic regression analysis showed that F3-F4 was associated with visceral obesity, IFG/diabetes, and low high-density lipoprotein ( HDL) cholesterol, but not triglycerides >150 or arterial hypertension. A significant interaction was found between age and visceral obesity ( P=.04). By stratifying patients for age, we confirmed the interaction between inclusion in the third age tertile (>54 years) and visceral obesity ( P=.04). In the lower (<41 years) and middle (41-54 years) age tertiles, the risk for F3-F4 fibrosis was mostly driven by visceral obesity and IFG/diabetes. This risk was higher in those with all three metabolic risk factors. Finally, among patients in the higher age tertile (>54 years), obesity did not affect the severity of fibrosis, and the risk of severe fibrosis was higher in those with low HDL and IFG/diabetes with/without visceral obesity (52%-54%). Conclusions Among patients with NAFLD, the metabolic profiles associated with risk for severe fibrosis varied among age groups. Low HDL, obesity and IFG/diabetes were prevalent among patients in the lower and middle age tertiles. HDL and IFG/diabetes but not visceral obesity were prevalent among those in the highest age tertile.
- Subjects
METABOLIC syndrome; FIBROSIS; FATTY liver; LOGISTIC regression analysis; OBESITY; HYPERTENSION
- Publication
Liver International, 2017, Vol 37, Issue 9, p1389
- ISSN
1478-3223
- Publication type
Article
- DOI
10.1111/liv.13397