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- Title
Role of denosumab before resection and reconstruction in giant cell tumors of bone: a single-centered retrospective cohort study.
- Authors
Sahito, Badaruddin; Ali, Sheikh Muhammad Ebad; Kumar, Dileep; Kumar, Jagdesh; Hussain, Nauman; Lakho, Tahir
- Abstract
Background: Denosumab has been approved by Food and Drug Authority in 2013 for use in surgically unresectable Giant cell tumor (GCT) to achieve resectable tumor margins. The aim of this study is to investigate the functional outcome and surgical convenience with the use of neoadjuvant denosumab before resection and reconstruction in Campanacci grade III GCT. Methods: We retrospectively reviewed 70 cases of Campanacci grade III GCT receiving resection and reconstruction between January 2014 and December 2019. They were stratified into two groups: one group of 29 patients received once-weekly denosumab 120 mg for 4-weeks before resection and reconstruction, while the other group of 41 patients did not receive denosumab before resection and reconstruction. Quality of life by musculoskeletal tumor society score where 0–7 means poor, 8–14 means fair, 15–22 means good; above 22 means excellent, incidence of tumor recurrence, intraoperative duration in minutes and postoperative positive margins were assessed for each cohort after 12 months follow-up. Results: There was no significant difference in musculoskeletal tumor society score (25.75 vs. 27.41; P = 0.178), incidence of recurrence (3.45% vs. 4.88%; P < 0.001), and postoperative positive margins (10.34% vs. 4.88%; P = 0.38) for both groups. However, the intraoperative duration (133.38 vs. 194.49; P < 0.001) was significantly higher in the non-denosumab group compared with denosumab group. Conclusions: Neoadjuvant denosumab is equally effective considering postoperative functional outcomes and surgical convenience except intraoperative duration where it is highly helpful in saving the operating time duration. Easier identification, resection and lesser reconstruction are the key surgical convenience offered by neoadjuvant denosumab.
- Subjects
THERAPEUTIC use of monoclonal antibodies; MUSCULOSKELETAL system diseases; SURGICAL therapeutics; FUNCTIONAL status; PLASTIC surgery; GIANT cell tumors; RETROSPECTIVE studies; MONOCLONAL antibodies; BONE tumors; TREATMENT effectiveness; QUALITY of life; POSTOPERATIVE period; DESCRIPTIVE statistics; COMBINED modality therapy; TUMOR grading; LONGITUDINAL method; EVALUATION
- Publication
European Journal of Orthopaedic Surgery & Traumatology, 2022, Vol 32, Issue 3, p567
- ISSN
1633-8065
- Publication type
Article
- DOI
10.1007/s00590-021-03012-1