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- Title
Cardiorespiratory fitness and inflammatory profile on cardiometabolic risk in adolescents from the LabMed Physical Activity Study.
- Authors
Agostinis-Sobrinho, César; Ruiz, Jonatan; Moreira, Carla; Abreu, Sandra; Luís, Lopes; Oliveira-Santos, José; Mota, Jorge; Santos, Rute; Agostinis-Sobrinho, César A; Ruiz, Jonatan R; Luís, Lopes; Oliveira-Santos, José
- Abstract
<bold>Purpose: </bold>We investigated the combined effect of cardiorespiratory fitness and the clustered score of inflammatory biomarkers (InflaScore) on the cardiometabolic risk score in adolescents.<bold>Methods: </bold>This is a cross-sectional analysis with 529 adolescents (267 girls) aged 12-18 years. The shuttle run test was used to assess cardiorespiratory fitness. Continuous scores of clustered inflammatory biomarkers (high sensitivity C-reactive protein, complement factors C3 and C4, fibrinogen and leptin); cardiometabolic risk score (systolic blood pressure, triglycerides, ratio total cholesterol/HDL, HOMA-IR and waist circumference) were computed.<bold>Results: </bold>Adolescents with a higher inflammatory profile had the highest cardiometabolic risk score; adolescents with high InflaScore and low fitness had the highest odds of having a high cardiometabolic risk (OR 16.5; 95% CI 7.8-34.5), followed by adolescents with a higher InflaScore but fit (OR 7.5; 95% CI 3.7-8.4), and then by adolescents with a low InflaScore and unfit (OR 3.7; 95% CI 1.6-8.4) when compared to those with low InflaScore and fit, after adjustments for age, sex, pubertal stage, adherence to a Mediterranean dietary pattern and socioeconomic status.<bold>Conclusions: </bold>The findings of our study suggest that the combination of high inflammatory state and low cardiorespiratory fitness is synergistically associated with a significantly higher cardiometabolic risk score and thus supports the relevance of early targeted interventions to promote physical activity and preservation as part of primordial prevention.
- Subjects
CARDIOVASCULAR disease treatment; BLOOD pressure; CARDIOVASCULAR diseases; YOUTH health; BIOMARKERS
- Publication
European Journal of Applied Physiology, 2017, Vol 117, Issue 11, p2271
- ISSN
1439-6319
- Publication type
journal article
- DOI
10.1007/s00421-017-3714-x