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- Title
Digital biomarkers for precision diagnosis and monitoring in Parkinson's disease.
- Authors
Sun, Yue-meng; Wang, Zhi-yun; Liang, Yuan-yuan; Hao, Chen-wei; Shi, Chang-he
- Abstract
Parkinson's disease (PD) is a multifactorial neurodegenerative disorder with high prevalence among the elderly, primarily manifested by progressive decline in motor function. The aging global demographic and increased life expectancy have led to a rapid surge in PD cases, imposing a significant societal burden. PD along with other neurodegenerative diseases has garnered increasing attention from the scientific community. In PD, motor symptoms are recognized when approximately 60% of dopaminergic neurons have been damaged. The irreversible feature of PD and benefits of early intervention underscore the importance of disease onset prediction and prompt diagnosis. The advent of digital health technology in recent years has elevated the role of digital biomarkers in precisely and sensitively detecting early PD clinical symptoms, evaluating treatment effectiveness, and guiding clinical medication, focusing especially on motor function, responsiveness and sleep quality assessments. This review examines prevalent digital biomarkers for PD and highlights the latest advancements.
- Subjects
PARKINSON'S disease diagnosis; DIGITAL technology; MOTOR ability; MOBILE apps; FACE; EYE movement disorders; ARM; TASK performance; DIGITAL health; TREATMENT effectiveness; PARKINSON'S disease; WEARABLE technology; GAIT disorders; MOVEMENT disorders; HYPOKINESIA; NEUROLOGICAL disorders; PARASYMPATHETIC nervous system; MEDICAL equipment; ACCURACY; SLEEP quality; REACTION time; SPEECH disorders; PUPIL (Eye); BIOMARKERS; SLEEP disorders; POSTURAL balance; SYMPTOMS
- Publication
NPJ Digital Medicine, 2024, Vol 7, Issue 1, p1
- ISSN
2398-6352
- Publication type
Article
- DOI
10.1038/s41746-024-01217-2