We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The role of exercise and PGC1α in inflammation and chronic disease.
- Authors
Handschin, Christoph; Spiegelman, Bruce M.
- Abstract
Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1α has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.
- Subjects
CHRONIC diseases; MUSCLE diseases; MUSCULAR dystrophy; SARCOPENIA; EXERCISE; PROTEINS; INFLAMMATION; PHYSIOLOGICAL adaptation; TUMOR necrosis factors
- Publication
Nature, 2008, Vol 454, Issue 7203, p463
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature07206