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- Title
Incidence of malignancy in multiple sclerosis: A cohort study in the Danish Multiple Sclerosis Registry.
- Authors
Nørgaard, Mette; Veres, Katalin; Sellebjerg, Finn T; Svingel, Lise S; Foch, Caroline; Boutmy, Emmanuelle; Sabidó, Meritxell; Magyari, Melinda
- Abstract
Background: The association between multiple sclerosis and malignancy is controversial and a current appraisal is needed. Objective: To determine the incidence of malignancy in patients with multiple sclerosis compared with the general population and in relation to disease-modifying therapy. Methods: Patients with multiple sclerosis (1995 – 2015) were matched by birth year and sex to individuals without multiple sclerosis in the general population. Patients with multiple sclerosis initiating disease-modifying therapy were evaluated using landmark period analysis. Malignancy risk was assessed by incidence rates, incidence rate ratios, and standardised incidence ratios. Results: The standardised incidence ratio of any malignancy (excluding non-melanoma skin cancer) in patients with multiple sclerosis (n = 10,557) was 0.96 (95% CI 0.88 – 1.06), and there was no increased incidence of specific malignancy types compared with the general population cohort (n = 103,761). At the 48-month landmark period, the age-adjusted incidence per 100,000 person-years of any malignancy (excluding non-melanoma skin cancer) was 436.7 (95% CI 361.0 – 512.4) in patients newly treated with immunomodulator-only and 675.1 (95% CI 130.4 – 1219.9) in patients newly treated with immunosuppressant-only. Conclusions: There was no increased incidence of malignancy overall or by type in patients with multiple sclerosis compared neither with the general population nor in relation to disease-modifying therapy.
- Subjects
DENMARK; SKIN cancer; MULTIPLE sclerosis; COHORT analysis
- Publication
Multiple Sclerosis Journal - Experimental, Translational & Clinical, 2021, Vol 7, Issue 4, p1
- ISSN
2055-2173
- Publication type
Article
- DOI
10.1177/20552173211053939