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- Title
Alcohol Intake and Renal Cell Cancer in a Pooled Analysis of 12 Prospective Studies.
- Authors
Jung Fun Lee; Hunter, David J.; Spiegelman, Donna; Adami, Hans-Olov; Albanes, Demetrius; Bernstein, Leslie; van den Brandt, Piet A.; Buring, Julie E.; Eunyoung Cho; Folsom, Aaron R.; Freudenheim, Jo L.; Giovannucci, Edward; Graham, Saxon; Horn-Ross, Pamela L.; Leitzmann, Michael F.; McCullough, Marjorie L.; Miller, Anthony B.; Parker, Alexander S.; Rodriguez, Carmen; Rohan, Thomas E.
- Abstract
Background The association between alcohol intake and risk of renal cell cancer has been inconsistent in case-control studies. An inverse association between alcohol intake and risk of renal cell cancer has been suggested in a few prospective studies, but each of these studies included a small number of cases. Methods We performed a pooled analysis of 12 prospective studies that included 530469 women and 229575 men with maximum follow-up times of 7–20 years. All participants had completed a validated food-frequency questionnaire at baseline. Using the primary data from each study, the study-specific relative risks (RRs) for renal cell cancer were calculated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. Results A total of 1430 (711 women and 719 men) cases of incident renal cell cancer were identified. The study-standardized incidence rates of renal cell cancer were 23 per 100000 person-years among nondrinkers and 15 per 100000 person-years among those who drank 15 g/day or more of alcohol. Compared with non-drinking, alcohol consumption (≥15 g/day, equivalent to slightly more than one alcoholic drink per day) was associated with a decreased risk of renal cell cancer (pooled multivariable RR = 0.72, 95% confidence interval = 0.60 to 0.86; Ptrend<.001); statistically significant inverse trends with increasing intake were seen in both women and men. No difference by sex was observed (Pheterogeneity = .89). Associations between alcohol intake and renal cell cancer were not statistically different across alcoholic beverage type (beer versus wine versus liquor) (P = .40). Conclusion Moderate alcohol consumption was associated with a lower risk of renal cell cancer among both women and men in this pooled analysis.
- Subjects
RENAL cell carcinoma; ALCOHOL drinking; RENAL cancer; CANCER research; SARCOMA; PATHOLOGY
- Publication
JNCI: Journal of the National Cancer Institute, 2007, Vol 99, Issue 10, p801
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djk181