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- Title
诱导化疗对鼻咽癌患者免疫功能及炎症指标的影响.
- Authors
吴倩; 王意; 陈念; 周凯; 田昕; 徐晖; 苟小霞
- Abstract
Objective To investigate the effect of induction chemotherapy (IC) on immune function and inflammatory markers in patients with stage Ⅲ-Ⅳ nasopharyngeal carcinoma (NPC). Methods A total of 102 patients with stage Ⅲ-Ⅳ NPC confirmed by pathology were selected to receive TPF regimen (docetaxel, cisplatin and 5-fluorouracil, 72 cases) or GP regimen (gemcitabine and cisplatin, 30 cases). The short-term clinical outcomes of patients were evaluated. The immune function of patients with different clinical characteristics was compared before and after IC treatment. T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+ /CD8+ ), B lymphocyte subsets (CD19+ ) and NK cell percentage in peripheral blood before and after IC were compared. Inflammatory markers interleukin-6, tumor necrosis factor α (TNF- α), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR), and systemic immunoinflammatory index (SII), and changes of total protein (TP), albumin (ALB) and prealbumin (PA) were also compared. The immune function, inflammatory index and nutritional status of patients with different IC regimen and IC cycle number were compared. Results All 102 patients completed IC, of which 0 patient achieved complete response (CR), 87 patients (85.3%) achieved partial response (PR), 13 patients (12.7%) achieved stable response (SD), 2 patients (2.0%) developed PD. The objective response rate (ORR) was 85.3%, and the disease control rate (DCR) was 98.0%. The proportion of CD19+ lymphocytes and NK cells decreased after IC, while the proportion of CD3+, CD4+ and CD8+ lymphocytes increased after IC (P<0.05). Levels of NLR, SII, TP, ALB and PA were decreased in NPC patients after IC (P<0.05). After IC, the CD4+ /CD8+ ratio was higher in the GP group than that in the TPF group, and LMR decreased (P<0.05). There were no significant differences in the immune function, inflammatory indexes and nutritional status before and after IC between the ≤3 cycle group and the > 3 cycle group. Conclusion IC is an effective therapy with high disease control rates for NPC patients, and can improve their cellular immune function, decrease humoral immune function, inflammatory indices and nutritional status.
- Publication
Tianjin Medical Journal, 2024, Vol 52, Issue 4, p397
- ISSN
0253-9896
- Publication type
Article
- DOI
10.11958/20230792