We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Removal of the Olfactory Bulbs in Mice Leads to Changes in Affective Behavior.
- Authors
Nedogreeva, O. A.; Stepanichev, Mu. Y.; Gulyaeva, N. V.
- Abstract
Removal of the olfactory bulbs induces a multitude of behavioral impairments, the most reproducible of which is hyperlocomotion. Olfactory bulbectomy is widely used to model anxiety and depression-like states. In the present study, C57Bl/6 mice subjected to olfactory bulbectomy were tested in standard tests to assess anxiety and depression-like behavior. Removal of the olfactory bulbs in mice was found to increase anxiety and emotionality. Attention in the present work was focused on the fact that hyperactivity induced by bulbectomy can seriously distort the results obtained in anxiety tests. The results lead to the conclusion that the contribution of hyperlocomotion must be taken into account in the interpretation of behavioral measures in the elevated plus maze test.
- Subjects
BEHAVIOR; OLFACTORY bulb; TEST anxiety; MICE; MAZE tests; SMELL
- Publication
Neuroscience & Behavioral Physiology, 2020, Vol 50, Issue 7, p892
- ISSN
0097-0549
- Publication type
Article
- DOI
10.1007/s11055-020-00982-3