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- Title
Natural course of kidney function in Type 2 diabetic patients with diabetic nephropathy.
- Authors
Christensen, P. K.; Rossing, P.; Nielsen, F. S.; Parving, H. -H.
- Abstract
SummaryAims To determine the natural course of kidney function and to evaluate the impact of putative progression promoters in Caucasian Type 2 diabetes mellitus (DM) patients with diabetic nephropathy who had never received any antihypertensive treatment. Methods A long-term observational study of 13 normotensive to borderline hypertensive Type 2 DM patients with diabetic nephropathy. Glomerular filtration rate (GFR) was measured approximately every year (51Cr-EDTA plasma clearance technique). Albuminuria, blood pressure (BP) and haemoglobin A1c (HbA1c) was determined 2–4 times per year and serum cholesterol every second year. Results The patients (12 males/one female), age 56 ± 9 (mean ± sd) years, with a known duration of diabetes of 10 ± 6 years, were followed for 55 (24–105) (median (range)) months. GFR decreased from 104 (50–126) to 80 (39–112) ml.min–1.1.73 m–2 (P = 0.002) with a median rate of decline of 4.5 (– 0.4 to 12) ml.min–1.year–1. During follow-up, albuminuria rose from 494 (301–1868) to 908 (108–2169) mg/24 h (P = 0.25), while BP, HbA1c and serum cholesterol remained essentially unchanged. In univariate analysis the rate of decline in GFR did not correlate significantly with neither baseline nor mean values during follow-up of BP, albuminuria, HbA1c and serum cholesterol. Conclusions Our study suggests that normotensive to borderline hypertensive Type 2 DM patients with diabetic nephropathy have a rather slow decline in kidney function, but we did not unravel the putative progression promoters responsible for the variation in rate of decline in GFR. Diabet. Med. 16, 388–394 (1999).
- Subjects
CAUCASUS; DIABETIC nephropathies; PEOPLE with diabetes
- Publication
Diabetic Medicine, 1999, Vol 16, Issue 5, p388
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1046/j.1464-5491.1999.00063.x