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- Title
Periovulatory Plasma Prolactin Response to Gonadotropin-Releasing Hormone: Role of Endogenous Opiates.
- Authors
De Marinis, Laura; Mancini, Antonio; D'Amico, Colomba; Calabró, Francesco; Zuppi, Paolo; Fiumara, Concetta; Barini, Angela
- Abstract
It has been previously shown that in normal women during the periovulatory period, prolactin (PRL) levels increase after the administration of nonspecific stimuli, such as growth hormone-releasing hormone or gonadotropin-releasing hormone (GnRH). In order to gain insight into the mechanism of this response, we have tested the effect of a naloxone infusion (1.6 mg/h) on the PRL response to GnRH in 5 normal females, aged 20-27 years, tested during the periovulatory period. Naloxone was administered starting 60 min before GnRH administration (100 μg as an i.v. bolus). Naloxone clearly blunted the PRL response (basal 10.7 ± 1.7 ng/ml, peak 11.8 ± 0.2 ng/ml at 30 min, versus: basal 9.0 ± 0.5 ng/ml, peak 20.6 ± 3.9 ng/ml at 45 min after GnRH alone; significance of difference between peaks: p < 0.05). A secondary late increase of PRL levels was observed, reaching about 60% of basal levels at 120 min (16.8 ± 2.6 ng/ml). These data indicate that periovulatory PRL dynamics are altered by naloxone administration and suggest a possible involvement of opioid peptides in the 'paradoxical' PRL response to GnRH in normal subjects. Copyright © 1990 S. Karger AG, Basel
- Publication
Neuroendocrinology, 1990, Vol 51, Issue 6, p717
- ISSN
0028-3835
- Publication type
Article
- DOI
10.1159/000125416