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- Title
Correlation Between CD133+ Stem Cells and Clinical Improvement in Patients with Autism Spectrum Disorders Treated with Intrathecal Bone Marrow-derived Mononuclear Cells.
- Authors
VILLARREAL-MARTINEZ, LAURA; MARTINEZ-GARZA, LAURA ELIA; RODRIGUEZ-SANCHEZ, IRAM PABLO; ALVAREZVILLALOBOS, NERI; GUZMANGALLARDO, FERNANDO; POPESALAZAR, SULIA; SALINAS-SILVA, CYNTHIA; CEPEDACEPEDA, MARIA GUADALUPE; GARZABEDOLLA, ALEJANDRA; DOMINGUEZVARELA, IRVING ARMANDO; VILLARREALMARTINEZ, DANIEL ZACARIAS; TREVINOVILLARREAL, JOSE HUMBERTO; GOMEZALMAGUER, DAVID
- Abstract
Autism spectrum disorders (ASDs) are a group of neurodevelopmental pathologies characterized by social and communication deficits, for which treatments are limited. Cell therapies, including intrathecal (IT) administration of bone marrow (BM) mononuclear cells (BM-MNC), improves symptoms in patients with ASD. Twenty-four patients diagnosed with ASD, according to the Diagnostic and Statistical Manual of Mental Disorders Text Revision Fourth Edition (DSM-IV-TR) criteria, were autologously treated with IT BM-MNC, and the clinical effect was evaluated using the Childhood Autism Rating Scale (CARS) on Days 30 (n=24) and 180 (n=14) post-treatment. IT BM-MNC improved clinical outcomes by Day 30 (p=0.0039), and those benefits remained and were further accentuated by Day 180 post-treatment (n=14; p=<0.0001). Clinical benefit at Days 30 (p=0.001; r= -0.51) and 180 (p=0.01; r= -0.60) posttreatment positively correlated with the enrichment of a putative BM stem cell population expressing the cluster of differentiation 133+ (CD133+) surface marker.
- Subjects
TREATMENT of autism; CLINICAL trials; CELLULAR therapy; STEM cells; DESCRIPTIVE statistics; BONE marrow; LONGITUDINAL method
- Publication
Innovations in Clinical Neuroscience, 2022, Vol 19, Issue 4-6, p78
- ISSN
2158-8333
- Publication type
Article