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- Title
Evidence for an additional metastatic route: in vivo imaging of cancer cells in the primo-vascular system around tumors and organs.
- Authors
Jung Sun Yoo; Hong Bae Kim; Nayoun Won; Jiwon Bang; Sungjee Kim; Saeyoung Ahn; Byung-Cheon Lee; Kwang-Sup Soh; Yoo, Jung Sun; Kim, Hong Bae; Won, Nayoun; Bang, Jiwon; Kim, Sungjee; Ahn, Saeyoung; Lee, Byung-Cheon; Soh, Kwang-Sup
- Abstract
<bold>Purpose: </bold>Researchers have been studying the mechanisms by which metastasis can be prevented via blocking the hematogenous and the lymphatic routes for a long time now. However, metastasis is still the single most challenging obstacle for successful cancer management. In a new twist that may require some retooling of this established approach, we investigated the hypothesis that tumor metastases can occur via an independent fluid-conducting system called the primo-vascular system.<bold>Procedures: </bold>The dissemination and growth of near-infrared quantum dot (NIR QD)-electroporated cancer cells in metastatic sites were investigated using in vivo multispectral imaging techniques.<bold>Results: </bold>Our results show that the NIR QD-labeled cancer cells were able to migrate through not only the blood vascular and lymphatic systems but also the primo-vascular system extending from around the tumor to inside the abdominal cavity. Furthermore, the NIR QD-labeled cancer cells, which had been seeded intraperitoneally, specifically infiltrated the primo-vascular system in the omentum and in the gonadal fat.<bold>Conclusions: </bold>These findings strongly suggest that the primo-vascular system may be an additional metastasis route, complementing the lymphatic and hematogenous routes, which facilitate the dissemination and colonization of cancer cells at secondary sites.
- Subjects
METASTASIS; CANCER treatment; ELECTROPORATION; CANCER cells; TUMORS; QUANTUM dots
- Publication
Molecular Imaging & Biology, 2011, Vol 13, Issue 3, p471
- ISSN
1536-1632
- Publication type
journal article
- DOI
10.1007/s11307-010-0366-1