We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Segmental peri-coronary epicardial adipose tissue volume and coronary plaque characteristics.
- Authors
Hassan, Mohamed; Said, Karim; Rizk, Hussien; ElMogy, Fatma; Donya, Mohamed; Houseni, Mohamed; Yacoub, Magdi
- Abstract
Aims Epicardial adipose tissue (EAT) has been proposed to modulate underlying coronary plaque features. The study aimed to determine the relation between segmental EAT (sEAT) volume, assessed by cardiac magnetic resonance (CMR), and underlying coronary plaque characteristics, as estimated by multidetector computed tomography (CT) (MDCT). Methods and results The study included 32 male patients with stable angina pectoris and 11 age-matched healthy controls. For each CAD patient, sEAT volume around 8 coronary segments (3 in left anterior descending artery, 3 in right coronary artery, and 2 in left circumflex artery) was quantified by CMR. By MDCT, plaques in each coronary segment were characterized in terms of plaque volume, type, CT attenuation, and severity of luminal stenosis. Serum levels of adipokines were measured. Total EAT volume was significantly higher in CAD patients than in control group. Serum resistin showed significant correlation with EAT volume (r = 0.69, P < 0.001). Analysis of 256 coronary segments showed larger sEAT volume with increasing luminal stenosis of the corresponding segment (mild: 8.2 cm³; moderate: 11 cm³; severe: 11.8 cm³, P < 0.001 ).sEAT volume was larger in segments with mixed than those with calcified or non-calcified plaques (12.1 vs. 10.2 vs. 9.5 cm³, respectively, P = 0.015). sEAT volume was larger in segments with low CT attenuation non-calcified plaques compared with non-calcified plaques with CT attenuation >30 HU (10.5 vs. 8.2 mm³, P < 0.001). Conclusion Peri-coronary epicardial adipose tissue volume is significantly associated with the extent and severity of coronary atherosclerosis and may be a determinant of plaque vulnerability.
- Subjects
ADIPOSE tissues; ANGINA pectoris; CORONARY disease; STATISTICAL correlation; PAIRED comparisons (Mathematics); CONTROL groups; CORONARY angiography; MULTIDETECTOR computed tomography
- Publication
European Heart Journal - Cardiovascular Imaging, 2016, Vol 17, Issue 10, p1169
- ISSN
2047-2404
- Publication type
Article
- DOI
10.1093/ehjci/jev298