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- Title
Coronary artery calcification is inversely related to body morphology in patients with significant coronary artery disease: a three-dimensional intravascular ultrasound study.
- Authors
Dangas, George D.; Maehara, Akiko; Evrard, Solene M.; Sartori, Samantha; Li, Jennifer R.; Chirumamilla, Amala P.; Nomura-Kitabayashi, Aya; Gukathasan, Nilusha; Hassanin, Ahmed; Baber, Usman; Fahy, Martin; Fuster, Valentin; Mintz, Gary S.; Kovacic, Jason C.
- Abstract
Aims Emerging data have indicated unexpected complexity in the regulation of vascular and bone calcification. In particular, several recent studies have challenged the concept of a universally positive relationship between body morphology [weight, height, body mass index (BMI), body surface area (BSA)] and the extent of vascular calcification. We sought to clarify these discrepancies and investigated the relationship between index lesion coronary artery calcification (CAC) and body morphology in patients undergoing percutaneous coronary intervention (PCI) using three-dimensional intravascular ultrasound (IVUS). Methods and results We analysed CAC in patients who underwent PCI with pre-intervention IVUS imaging. The main outcome measure was the calcium index (CalcIndex); a three-dimensional IVUS-derived measure of total calcification per obstructive coronary lesion. A total of 346 patients (65.3 ± 10.6 years; 29.5% females) underwent PCI with IVUS-based CAC assessment. CalcIndex was categorized as zero–low (0–0.1399; n = 152) or intermediate–high (0.1400–1.2541; n = 194). All measures of body morphology were lower in patients with intermediate–high CalcIndex (height, P = 0.024; weight, P = 0.008; BMI, P = 0.064; BSA, P = 0.005). In adjusted multivariable models, weight and BSA were independent inverse predictors of intermediate–high CalcIndex [weight: odds ratio (OR) 0.986, P = 0.017; BSA: OR 0.323, P = 0.012] while CalcIndex also trended towards an inverse association with both height (P = 0.068) and BMI (P = 0.064). These independent inverse associations were consistent across multiple clinical subgroups, including stratification by age, race, gender, diabetes, and renal impairment. Conclusion Using three-dimensional IVUS to assess vascular calcification, these data confirm an independent, inverse relationship between body size and index lesion CAC in patients with obstructive coronary artery disease.
- Subjects
CORONARY artery physiology; DIAGNOSIS; CORONARY disease; HEART disease risk factors; KIDNEY disease diagnosis; SMOKING; OBESITY complications; CALCINOSIS; ADRENERGIC beta agonists; ASPIRIN; BODY weight; CALCIUM; CARDIOVASCULAR diseases risk factors; CHI-squared test; DIAGNOSTIC imaging; ECHOCARDIOGRAPHY; ETHNIC groups; FISHER exact test; CARDIAC patients; EVALUATION of medical care; MEDICAL needs assessment; METABOLISM; MINERALS; RACE; STATISTICS; ULTRASONIC imaging; COMORBIDITY; STATINS (Cardiovascular agents); DATA analysis; BODY mass index; CLOPIDOGREL; DESCRIPTIVE statistics
- Publication
European Heart Journal - Cardiovascular Imaging, 2014, Vol 15, Issue 2, p201
- ISSN
2047-2404
- Publication type
Article
- DOI
10.1093/ehjci/jet139