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- Title
Nomogram Prediction Model of Hypernatremia on Mortality in Critically Ill Patients.
- Authors
Qi, Zhili; Lu, Jiaqi; Liu, Pei; Li, Tian; Li, Ang; Duan, Meili
- Abstract
Mildly elevated sodium concentration levels as well as hypernatremia have previously been shown to place patients at increased risk of death.27-29 Hypernatremia could increase mortality in critical patients independent of comorbidities.[10],30-34 A study found that the hospital mortality rate of patients with hospital-acquired hypernatremia was 29%.[35] However, it is unclear whether hypernatremia directly reduces survival or whether it is a surrogate marker for more severe disease states. A retrospective study of 152 ICU patients showed that hypernatremia was an independent risk factor for mortality in ICU patients.[39] One study reported a statistically significant sequential relationship between the severity of hypernatremia and the proportion of patients with dementia among hospitalized patients with a mean age of 81 years: mild hypernatremia (146-150 mmol / L) (76%), moderate hypernatremia (151-159 mmol / L) (83%), and severe hypernatremia (>= 160 mmol / L) (98%).[40] In patients with aneurysmal subarachnoid hemorrhage, hypernatremia was associated with increased mortality and a worse prognosis.[41] An increase in plasma sodium concentration had also been shown to induce arterial structural remodeling,[42] increased arterial oxidative stress,[43] collagen deposition, and tube wall thickening with lumen narrowing.[44] All of these changes contribute to an increase or maintenance of arterial tone and peripheral vascular total resistance, which causes blood pressure to increase. In turn, to clarify the risks of electrolyte disturbances in critically ill patients in the ICU, early intervention for high-risk patients should be conducted to enhance the quality of patient survival.
- Subjects
HYPERNATREMIA; CRITICALLY ill; INTESTINAL physiology; NOMOGRAPHY (Mathematics); DRINKING (Physiology); PREDICTION models; INAPPROPRIATE ADH syndrome
- Publication
Infection & Drug Resistance, 2023, Vol 16, p143
- ISSN
1178-6973
- Publication type
Article
- DOI
10.2147/IDR.S387995