We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Beta2-microglobulin clearance with super high flux hemodialysis: an ex vivo study.
- Authors
Lee, W C R; Uchino, S; Fealy, N; Baldwin, I; Panagiotopoulos, S; Goehl, H; Morgera, S; Neumayer, H H; Bellomo, R
- Abstract
<bold>Background: </bold>Beta2m accumulation induces disease in patients with end-stage renal failure (ESRF). Thus, its removal from patients with ESRF appears desirable. Current dialysis technology, however, has limited effectiveness.<bold>Aims: </bold>To measure beta2m clearance with a novel super high flux membrane.<bold>Design: </bold>Ex vivo experimental study.<bold>Setting: </bold>Intensive Care Laboratory of Tertiary institution.<bold>Subjects: </bold>Six volunteers.<bold>Measurements and Results: </bold>At a blood flow of 300 ml/min, the clearance of beta2-MG increased from 113.5 +/- 38.5 ml/min with a dialysate flow rate of 200 ml/min to 184.8 +/- 61.1 ml/min with a flow rate of 300 ml/min and 195.0 +/- 60.0 ml/min with a 500 ml/min flow rate. The clearance of albumin was 4.5 ml/min with a dialysate flow rate of 200 ml/min, 5.2 ml/min for a flow rate of 300 ml/min and 5.8 ml/min for a flow rate of 500 ml/min.<bold>Conclusions: </bold>High levels of beta2m clearance can be achieved with a super high flux membrane while albumin losses remain limited.
- Subjects
TREATMENT of chronic kidney failure; BLOOD proteins; CHRONIC kidney failure; COMPARATIVE studies; CONFIDENCE intervals; GLOBULINS; HEMODIALYSIS; RESEARCH methodology; MEDICAL cooperation; ARTIFICIAL membranes; RESEARCH; EVALUATION research
- Publication
International Journal of Artificial Organs, 2003, Vol 26, Issue 8, p723
- ISSN
0391-3988
- Publication type
journal article
- DOI
10.1177/039139880302600804