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- Title
Association of mean arterial pressure with all-cause and cardiovascular mortality in young adults.
- Authors
Shuo Sun; Kenneth Lo; Lin Liu; Jiayi Huang; Ying Qing Feng; Ying-ling Zhou; Yu-Qing Huang; Sun, Shuo; Lo, Kenneth; Liu, Lin; Huang, Jiayi; Feng, Ying Qing; Zhou, Ying-Ling; Huang, Yu-Qing
- Abstract
<bold>Background: </bold>Mean arterial pressure (MAP) is a predictor of all-cause and cardiovascular disease (CVD) mortality in middle-aged population and elderly, but less evidence has been shown in young adults.<bold>Objectives: </bold>We examined the associations of MAP with all-cause and CVD mortality in young adults aged between 18 and 40 years.<bold>Methods: </bold>Data were from the National Health and Nutrition Examination Survey (1999-2006) and participants were followed up to 31 December 2015. MAP was categorised by quartiles. Multivariable Cox proportional hazards models and Kaplan-Meier survival curves were performed to estimate the association between MAP, all-cause and CVD mortality.<bold>Results: </bold>There were a total of 8356 (4598 women (55.03%)) participants with the mean age of 26.63±7.01 years, of which 265 (3.17%) and 10 (0.12%) cases of all-cause and cardiovascular mortality occurred during a median follow-up duration of 152.96±30.45 months, respectively. There was no significant difference in the survival rate by MAP quartiles (p=0.058). When MAP was treated as a continuous variable, the multivariable adjusted HRs for all-cause and CVD mortality were 1.00 (95% CI 0.96 to 1.04; p=0.910) and 0.94 (95% CI 0.77 to 1.14; p=0.529), respectively. When using the lowest quartile (Q1) as referent, the adjusted HRs for all-cause mortality from Q2 to Q4 were 1.16 (95% CI 0.56 to 2.42), 1.06 (95% CI 0.48 to 2.32) and 0.91 (95% CI 0.37 to 2.24; p for tend was 0.749) after adjusting for potential confounders.<bold>Conclusion: </bold>There was no significant association of MAP with all-cause and CVD mortality in young adults with a relatively short follow-up time.
- Subjects
CARDIOVASCULAR diseases; YOUNG adults; HEALTH &; Nutrition Examination Survey; PROPORTIONAL hazards models
- Publication
Postgraduate Medical Journal, 2020, Vol 96, Issue 1138, p455
- ISSN
0032-5473
- Publication type
journal article
- DOI
10.1136/postgradmedj-2019-137354