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- Title
Human Immunodeficiency Virus Infection Is a Major Risk Factor for Detection of Human Papillomavirus DNA in Esophageal Brushings.
- Authors
Trottier, Anne-Marie; Coutlée, François; Leduc, Raymond; Ghattas, Georges; Toma, Emil; Allaire, Guy; Gaboury, Louis; Ghadirian, Parviz
- Abstract
The presence of human papillomavirus (HPV) DNA in esophageal brushings from human immunodeficiency virus (HIV)-seropositive hosts was investigated in a cross-sectional study. Oral and esophageal brushings from individuals scheduled for esophagogastroscopy (53 HIV-positive and 61 age-matched HIV-negative patients) were tested for the presence of HPV DNA by a consensus L1 polymerase chain reaction assay. HPV DNA was detected in esophageal brushings of 9 (17%) of the 53 HIV-seropositive patients and 0 of the 61 HIV-negative individuals. HPV-16 DNA was the most frequently detected. No proliferative mucosal lesion was noted in individuals with HPVpositive esophageal brushings. Cytological smears were done for 6 of the 9 patients with HPVpositive esophageal brushings, and epithelial atypia was recorded for 1. HIV infection and a history of genital herpes were strong independent predictors of HPV, suggesting that HPV is transmitted sexually in the esophagus.
- Publication
Clinical Infectious Diseases, 1997, Vol 24, Issue 4, p565
- ISSN
1058-4838
- Publication type
Article