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- Title
In Vivo Gold Complex Catalysis within Live Mice.
- Authors
Tsubokura, Kazuki; Vong, Kenward K. H.; Pradipta, Ambara R.; Ogura, Akihiro; Urano, Sayaka; Tahara, Tsuyoshi; Nozaki, Satoshi; Onoe, Hirotaka; Nakao, Yoichi; Sibgatullina, Regina; Kurbangalieva, Almira; Watanabe, Yasuyoshi; Tanaka, Katsunori
- Abstract
Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin-AuIII complex was designed and developed that enables organ-specific, localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5- and TAMRA-linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.
- Subjects
GOLD catalyst activity; CATALYSIS; LABORATORY mice; GLYCOSYLATED hemoglobin; AMIDATION; THERAPEUTICS
- Publication
Angewandte Chemie International Edition, 2017, Vol 56, Issue 13, p3579
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201610273