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- Title
Spatial, Hysteretic, and Adaptive Host-Guest Chemistry in a Metal-Organic Framework with Open Watson-Crick Sites.
- Authors
Cai, Hong; Li, Mian; Lin, Xiao‐Rong; Chen, Wei; Chen, Guang‐Hui; Huang, Xiao‐Chun; Li, Dan
- Abstract
Biological and artificial molecules and assemblies capable of supramolecular recognition, especially those with nucleobase pairing, usually rely on autonomous or collective binding to function. Advanced site-specific recognition takes advantage of cooperative spatial effects, as in local folding in protein-DNA binding. Herein, we report a new nucleobase-tagged metal-organic framework (MOF), namely ZnBTCA (BTC=benzene-1,3,5-tricarboxyl, A=adenine), in which the exposed Watson-Crick faces of adenine residues are immobilized periodically on the interior crystalline surface. Systematic control experiments demonstrated the cooperation of the open Watson-Crick sites and spatial effects within the nanopores, and thermodynamic and kinetic studies revealed a hysteretic host-guest interaction attributed to mild chemisorption. We further exploited this behavior for adenine-thymine binding within the constrained pores, and a globally adaptive response of the MOF host was observed.
- Subjects
METAL-organic frameworks; SUPRAMOLECULAR chemistry; HYSTERESIS; BASE pairs; MOLECULES; ADENINE
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 36, p10454
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201502045