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- Title
Hydrodynamic characteristics of a membrane oxygenator: modeling of pressure-flow characteristics and their influence on apparent viscosity.
- Authors
Okahara, S.; Tsuji, T.; Ninomiya, S.; Miyamoto, S.; Takahashi, H.; Soh, Z.; Sueda, T.
- Abstract
The viscosity obtained from pressure-flow characteristics of an oxygenator may help to detect factors that change oxygenator resistance. The objective of this study was to model pressure-flow characteristics of a membrane oxygenator with an integrated arterial filter and to quantify their influence on apparent viscosity of non-Newtonian fluids. One Newtonian fluid (glycerin solution) and two non-Newtonian fluids (whole bovine blood and a human red blood cell suspension) were perfused through an oxygenator and their pressure-flow characteristics examined systematically. Four resistance parameters for the pressure gradient characteristics approximation equation were obtained by the least squares method from the relational expression of pressure-flow characteristics and viscosity. For all three fluids, a non-linear flow to pressure change was observed with a coefficient of determination of almost 1 by exponential approximation. The glycerin solution had a higher pressure gradient (10-70%) than the other fluids; the apparent viscosity of the non-Newtonian fluids was around 35% lower than the static one measured by a torsional oscillation viscometer. Overall, our study demonstrated that the influence on the apparent viscosity of non-Newtonian fluids can be quantified by pressure gradient differences in a membrane oxygenator with an integrated arterial filter.
- Subjects
JAPAN; ACADEMIC medical centers; BLOOD viscosity; BLOOD pressure; CARDIOPULMONARY bypass; EXTRACORPOREAL membrane oxygenation; HEMODYNAMICS; SURGICAL equipment; IN vitro studies
- Publication
Perfusion, 2015, Vol 30, Issue 6, p478
- ISSN
0267-6591
- Publication type
Article
- DOI
10.1177/0267659114562101