We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Skeletal muscle mitochondrial myopathy as a cause of exercise intolerance in a horse.
- Authors
Valberg, Stephanie J.; Carlson, Gary P.; Cardinet, George H.; Birks, Eric K.; Jones, James H.; Chomyn, Anne; DiMauro, Salvatore
- Abstract
Although exertional myopathies are commonly recognized in horses, specific etiologies have not been identified. This is the first report in the horse of a deficiency of Complex I respiratory chain enzyme associated with profound exercise intolerance. Physical examination, routine blood tests, endoscopy, and ultrasonograms of the heart and iliac arteries were unremarkable. With slow, incremental exercise (speeds 1.5-7 m/s), the Arabian mare showed a marked lactic acidosis, increased mixed venous PVO2, and little change in oxygen consumption. Muscle biopsies contained large accumulations of mitochondria with bizarre cristae formations. Biochemical analyses revealed a very low activity of the first enzyme complex in the mitochondrial respiratory chain (NADH CoQ reductase). The exercise intolerance and muscle stiffness in this horse were attributed to a profound lactic acidosis resulting from impaired oxidative energy metabolism during exercise. © 1994 John Wiley & Sons, Inc.
- Publication
Muscle & Nerve, 1994, Vol 17, Issue 3, p305
- ISSN
0148-639X
- Publication type
Article
- DOI
10.1002/mus.880170308