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- Title
Human peripheral nerve sheath neoplasm: Expression of Schwann cell-related markers and their relation to malignant transformation.
- Authors
Yasuda, Takeshi; Sobue, Gen; Ito, Takayuki; Doyu, Manabu; Sugiura, Isao; Hashizume, Yoshio; Kato, Kanefusa
- Abstract
We immunohistochemically examined the expression of Schwann cellrelated markers, nerve growth factor (NGF) receptor, S-100 α- and b̃-proteins, glial fibrillary acidic protein (GFAP), and galactocerebroside (gal C) in 5 malignant schwannomas, 21 benign peripheral nerve sheath tumors, and 4 apparently normal sural nerves. NGF receptor was expressed in the malignant schwannomas and benign peripheral nerve sheath tumors, but not in the endoneurium of apparently normal peripheral nerves. S-100 α-protein was observed in malignant schwannomas and in some neurofibroma cells. All cases were strongly positive for S-100 b̃-protein but were negative for GFAP and gal C. Our results suggest that these Schwann cell-related markers may be useful in identifying peripheral nerve sheath neoplasms as well as their malignant transformation.
- Publication
Muscle & Nerve, 1991, Vol 14, Issue 9, p812
- ISSN
0148-639X
- Publication type
Article
- DOI
10.1002/mus.880140903