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- Title
Analysis of 1379 patients with nasopharyngeal carcinoma treated by radiation.
- Authors
Qin, Dexing; Hu, Yuhua; Yan, Jiehua; Xu, Guozhen; Cai, Weiming; Wu, Xuelin; Cao, Dexian; Gu, Xianzhi; Qin, D X; Hu, Y H; Yan, J H; Xu, G Z; Cai, W M; Wu, X L; Cao, D X; Gu, X Z
- Abstract
One thousand three hundred seventy-nine nasopharyngeal carcinoma (NPC) patients were treated from March 1958 to December 1978. Twenty-two percent had stage I or II and 78% Stage III or IV had lesions. Two hundred twenty-Kv radiographs were used before 1960; and telecobalt was used from 1961 to 1978. Factors influencing the 5-year survival rate favorably are youth of patient, being female, pathologic condition (poorly differentiated carcinoma, 45.1% versus adenocarcinoma, 13%), stage (Stage I, 86%, Stage II, 59.5%; Stage III, 45.8%; Stage IV, 29.2%), decade admitted for treatment in the past (31% in the 1950s, 48.6% in the 1970s), total dose delivered to the nasopharynx (40 to 49 Gy, 46%; 70 to 79 Gy, 54.1%; 90 Gy or more, 64%) and prophylactic radiation to the neck regions (with prophylactic irradiation, 53.8%, without prophylactic irradiation, 23%). This implies that prophylactic radiation of the neck is crucial even without positive clinical metastasis. For those who have a residual tumor in the primary site when 70 Gy has been delivered, the total dose may be boosted to more than 90 Gy with the cone-down technique or on basis of adding 20 Gy to the dose at which the primary lesion disappeared grossly. The common postirradiation complications are: radiation myelitis, trismus, and otitis media. Because disease recurred in some patients after the fifth year, NPC patients should be followed for at least 10 years.
- Publication
Cancer (0008543X), 1988, Vol 61, Issue 6, p1117
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19880315)61:6<1117::AID-CNCR2820610611>3.0.CO;2-J