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- Title
Successful non-neurotoxic therapy (without radiation) of a multifocal primary brain lymphoma with a methotrexate, vincristine, and BCNU protocol (DEMOB).
- Authors
Cohen, Ian J.; Vogel, Ruth; Matz, Shoshana; Weitz, Raphael; Mor, Celia; Stern, Sidi; Zaizov, Rina; Cohen, I J; Vogel, R; Matz, S; Weitz, R; Mor, C; Stern, S; Zaizov, R
- Abstract
A 3.5-year-old boy with a multifocal primary lymphoma of the brain was treated successfully without neurotoxicity with a treatment regimen that did not include radiation. The protocol of Dexacort (dexamethasone), methotrexate, Oncovin (vincristine), and BCNU (carmustine) (DEMOB), which was developed with the use of MTX pharmacokinetic studies, was given over 7.5 months, and resulted in tumor disappearance on computerized tomography scans and marked improvement in clinical status. The patient remains in good health 3 years after diagnosis (March 1985).
- Subjects
ANTINEOPLASTIC agents; BRAIN tumors; DYNAMICS; LYMPHOMAS; METHOTREXATE; VINCRISTINE; DEXAMETHASONE; CARMUSTINE
- Publication
Cancer (0008543X), 1986, Vol 57, Issue 1, p6
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19860101)57:1<6::AID-CNCR2820570104>3.0.CO;2-B