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- Title
Endodermal sinus tumor of the vagina and cervix.
- Authors
Copeland, Larry J.; Sneige, Nour; Ordonez, Nelson G.; Hancock, Kenneth C.; Gershenson, David M.; Saul, Patton B.; Kavanagh, John J.; Copeland, L J; Sneige, N; Ordonez, N G; Hancock, K C; Gershenson, D M; Saul, P B; Kavanagh, J J
- Abstract
This report describes six patients with endodermal sinus tumor of the vagina and cervix, a polypoid friable tumor whose clinical presentation in girls younger than age 3 years simulates the presentation of sarcoma botryoides. In four of the six patients, the referring diagnosis was sarcoma botryoides. Five patients were treated with excisional surgery, and all six with chemotherapy. One patient with pulmonary metastases maintained a complete clinical response to vincristine, actinomycin-D, and cyclophosphamide (VAC) for 11 months. This is the first report of such a response. One patient with a vaginal lesion remains clinically free of disease 2 years after local excision and 18 months of VAC chemotherapy. This is the first report of apparently successful therapy that allowed retention of childbearing potential. Four of the six patients have been disease-free from 2 to 23 years. After examining the world literature, it is concluded that a combination of chemotherapy and surgery offers a reasonable prospect of cure with a minimum of serious side effects.
- Publication
Cancer (0008543X), 1985, Vol 55, Issue 11, p2558
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19850601)55:11<2558::AID-CNCR2820551107>3.0.CO;2-J