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- Title
In This Issue.
- Authors
Elder, James T.
- Abstract
Keratinocytes are highly sensitive to the proliferative, pro-survival, and pro-migratory effects of multiple epidermal growth factor receptor ligands, including EGF, transforming growth factor-α (TGF-α), heparin-binding EGF-like growth factor, amphiregulin, and epiregulin. The present findings are of additional interest because elastase is a serine protease, rather than a metalloproteinase, and because they provide a novel mechanism by which the presence of neutrophils in the upper layers of psoriatic epidermis might contribute to epidermal hyperplasia in psoriasis. TGF-α is highly expressed in the suprabasal layers of the epidermis, where neutrophils tend to collect in psoriasis lesions.
- Subjects
KERATINOCYTES; CYTOKINES; GROWTH factors; EPIDERMAL growth factor; SERINE proteinases; METALLOPROTEINASES
- Publication
Journal of Investigative Dermatology, 2004, Vol 123, Issue 2, pvi
- ISSN
0022-202X
- Publication type
Editorial
- DOI
10.1111/j.0022-202X.2004.23240.x